The Relationship between Normal Cerebral Perfusion Patterns and White Matter Lesion Distribution in 1,249 Patients with Multiple Sclerosis

Journal of Neuroimaging, 05/04/2012

Chronic plaques were more prevalent in white matter (WM) regions with lower relative perfusion. Lesions in more highly perfused regions were more commonly observed in early relapsing–remitting (RR) multiple sclerosis (MS) and therefore, may be more likely to successfully remyelinate and resolve.

Methods

  • WM lesions were identified and quantified on a single magnetic resonance imaging scan from 1,249 patients with MS.
  • The spatial distribution of lesions was compared between early RR, late RR, and SP MS in the context of normal cerebral perfusion patterns provided by a single-photon emission-computed tomography atlas of healthy individuals.

Results

  • Patients with SP MS had more distinct and larger lesions than patients with RR MS.
  • Across all subjects, lesions were present in regions of relatively lower normal perfusion than normal appearing WM.
  • Further, lesions in SP MS were more common in areas of lower perfusion as compared to the lesion distribution in early and late RR MS.

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