The Tumor Microenvironment Strongly Impacts Master Transcriptional Regulators and Gene Expression Class of Glioblastoma
The American Journal of Pathology, 05/04/2012Cooper LAD et al.
High expression levels of the master mesenchymal factors C/EBP–β, C/EBP–δ, and STAT3 were associated with a poor prognosis. Strong, specific expression of C/EBP–β and C/EBP–δ by hypoxic, perinecrotic cells in glioblastoma (GBM) likely account for their tight association with necrosis and may be related to their poor prognosis.
MDLinx connects healthcare professionals and patients to tomorrow's important medical news, while providing the pharmaceutical and healthcare industries with highly targeted interactive marketing, education, content, and medical research solutions.