Voxelwise analysis of conventional magnetic resonance imaging to predict future disability in early relapsing–remitting multiple sclerosis
Multiple Sclerosis Journal, 04/16/2012
The assessment of lesion location at the first stage of multiple sclerosis may be of value to predict future clinical disability.
This study included 38 patients with a CIS.
At inclusion, 10 out of 38 patients fulfilled the 2010 revised McDonald’s criteria for the diagnosis of multiple sclerosis.
Expanded Disability Status Scale (EDSS) evaluation was performed at baseline, year 1 and year 5, and cognitive evaluation at baseline and year 5.
T2-weighted MRI was performed at baseline and year 1.
The authors used voxelwise analysis to analyse the predictive value of lesions location for subsequent disability.
Using the global approach, no correlation was found between MRI and clinical data.
The occurrence or growth of new lesions in the brainstem was correlated with EDSS changes over the 5 years of follow-up.
The occurrence or growth of new lesions in cerebellum, thalami, corpus callosum and frontal lobes over 1 year was correlated with cognitive impairment at 5 years.