A longitudinal study of age- and gender-related annual rate of volume changes in regional gray matter in healthy adults

Human Brain Mapping, 04/13/2012

A significant positive correlation between the annual rate of gray matter volume change and age indicates that the region shows not linear but accelerated gray matter loss with age. Therefore, evaluating the annual rate of the gray matter volume change with age in healthy subjects is important in understanding how gray matter volume changes with aging in each brain region and in anticipating what cognitive functions are likely to show accelerated decline with aging.

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