Vitamin D insufficiency and mild cognitive impairment: cross-sectional association
European Journal of Neurology, 03/19/2012Annweiler C et al.
Low 25OHD concentrations were associated with mild cognitive impairment (MCI) status in older non–demented community–dwellers with subjective memory complaint.
Ninety-five non-demented Caucasian community-dwellers with subjective memory complaint (mean, 71.1 ± 6.4 years; 54.7% women) included in the Gait and Alzheimer Interaction Tracking (GAIT) study were categorized into two groups.
Serum 25OHD concentration was divided into quartiles, the fourth quartile corresponding to the highest 25OHD concentration.
The cross-sectional associations between 25OHD concentrations and MCI were modeled using logistic regressions.
Age, gender, body mass index, number of comorbidities, education level, Mini-Mental State Examination score, Frontal Assessment Battery score, Geriatric Depression Scale score, creatinine clearance, and season tested were considered as potential confounders.
Compared to CHI, patients with MCI (n = 43; mean, 71.4 ± 5.6 years; 34.9% women) had lower mean serum 25OHD concentrations (P = 0.006) and belonged more often to the lower quartiles compared to the highest quartile (P = 0.03).
Increased serum 25OHD concentration was associated with a lower risk of MCI [adjusted odds ratio (OR) = 0.96, P = 0.002].
Accordingly, lower quartiles of 25OHD were positively associated with MCI whilst using the highest quartile as reference (adjusted OR = 25.46, P = 0.002 for the first quartile; adjusted OR = 6.89, P = 0.03 for the second quartile; and adjusted OR = 10.29, P = 0.02 for the third quartile).
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