Evidence of Intrathecal Immunoglobulin Synthesis in Stroke: A Cohort Study

JAMA Neurology, 03/16/2012

The strong association between cerebrospinal fluid (CSF)–specific immunoglobulin synthesis and stroke suggests a role in the development of cerebral ischemia and might constitute an immunologically defined stroke subgroup.


  • Patients (n = 318) with stroke who were undergoing lumbar puncture during diagnostic workup and 79 control patients.


  • Cerebrospinal fluid-specific immunoglobulin (IgG, IgM, and IgA) synthesis was significantly (P < .001) more frequent after stroke (24.8%) compared with the incidence in age- and sex-matched controls (2.5%).
  • Furthermore, 31.3% of stroke patients demonstrated blood-brain barrier dysfunction and 18.1% displayed pleocytosis.

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