The Novel WHO 2010 Classification for Gastrointestinal Neuroendocrine Tumours Correlates Well with the Metastatic Potential of Rectal Neuroendocrine Tumours

Neuroendocrinology, 02/28/2012

The results show that rectal NETs classified as G1 according to the WHO 2010 classification have an indolent clinical course, whereas G2 NETs often metastasise. The WHO 2010 classification of NETs predicts the metastatic potential of rectal NETs better than the WHO 2000 classification.


  • The authors retrospectively classified 73 rectal NETs according to the novel WHO 2010 and the previous WHO 2000 classifications.
  • The aim was to assess the validity of the classifications in distinguishing indolent rectal NETs from metastasising tumours.


  • Using the WHO 2010 criteria, they identified 61 G1 tumours, none of which had metastasised during follow-up.
  • Of 11 G2 tumours, 9 had shown distant metastases.
  • The only G3 neuroendocrine carcinoma that occurred had been disseminated at initial presentation.

Print Article Summary Cat 2 CME Report