Sun Exposure, Vitamin D Intake and Progression to Disability among Veterans with Progressive Multiple Sclerosis
Neuroepidemiology , 08/05/2011
McDowell TY et al. – These results suggest that exposure to vitamin D before Multiple Sclerosis(MS) onset might slow disease–related neurodegeneration and thus delay progression to disability among patients with the progressive subtype.
Among veterans in the Multiple Sclerosis Surveillance Registry, 219 reported having the progressive form and met the inclusion criteria.
Participants reported their past sun exposure, vitamin D-related intake and age at disability milestones using the Patient-Determined Disease Steps (PDDS).
Cox proportional hazards model was used to examine the association between vitamin D-related exposures and time (years) to disability.
Low average sun exposure in the fall/winter before disease onset was associated with an increased risk of progressing to a PDDS score of 8 (hazard ratio, HR: 2.13, 95% confidence interval, CI: 1.20-3.78), whereas use of cod liver oil during childhood and adolescence was associated with a reduced risk (HR: 0.44, 95% CI: 0.20-0.96).
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