Wine drinking and essential tremor: A possible protective role

Movement Disorders, 04/21/2011

Nicoletti A et al. – The study’s data suggest a negative association between wine drinking and essential tremor, which could be explained by the long–term neuroprotective effect of its antioxidant components.


  • Cases and controls were enrolled from 6 Movement Disorder centers in central-southern Italy.
  • Essential tremor was diagnosed according to Bain's criteria.
  • 3 unrelated healthy controls (not affected by neurological disorders) per each enrolled case, matched by sex and age (±5 years), were selected.
  • Standardized questionnaire was administered to record demographic, epidemiological, and clinical data.
  • All cases and controls underwent a standard neurological examination.
  • Adjusted odds ratios and 95% confidence intervals were estimated using conditional logistic regression for the matched cases and controls.
  • 83 patients with essential tremor (38 men and 45 women; mean age, 68.2 ± 8.6 years) and 245 matched control subjects (113 men and 132 women; mean age, 68.4 ± 9.7 years) were enrolled in the study.


  • Multivariate analysis showed a significant negative association between essential tremor and wine consumption preceding the onset of disease (adjusted odds ratio, 0.23; 95% confidence interval, 0.08-0.64; P = .0005) with a significant dose effect (1-2 glass of wine per day: odds ratio, 0.32; 95% confidence interval, 0.10-0.95; P = .04; more than 3 glass of wine per day: odds ratio, 0.14; 95% confidence interval, 0.03–0.62; P = .01).
  • No association between essential tremor and cigarette smoking or coffee drinking was found.

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