Kelley NE et al. – The overall percentage of patients with pain relief after taking sumatriptan was equivalent to that observed with droperidol or prochlorperazine.

• Using the terms (“migraine” AND “emergency”) AND (“therapy” OR “treatment”), the author searched MEDLINE for reports from ED and urgent care settings that involved all routes of medication delivery.
• Reports from headache clinic settings were included only if medications were delivered by a parenteral route.

• Seventy–five reports were identified that compared the efficacy and safety of multiple acute migraine medications for rescue.
• Of the medications reviewed in Part 3, opioids, NSAIDs, and steroids all demonstrated some effectiveness.
• When used alone, nalbuphine and metamizole were superior to placebo.
• NSAIDs were inferior to the combination of metoclopramide and diphenhydramine.
• Meperidine was arguably equivalent when compared with ketorolac and dihydroergotamine (DHE) but was inferior to chlorpromazine and equivalent to the other dopamine antagonists.
• Steroids afford some protection against headache recurrence after the patient leaves the treatment center. /li>