1Primary familial brain calcification with known gene mutations: a systematic review and challenges of phenotypic characterizationJAMA Neurology  Clinical Article  Evidence Based Medicine
2A multiancestral genome-wide exome array study of Alzheimer disease, frontotemporal dementia, and progressive supranuclear palsyJAMA Neurology  Clinical Article  Evidence Based Medicine
3Effects of repetitive transcranial magnetic stimulation on motor symptoms in Parkinson disease: a systematic review and meta-analysisJAMA Neurology  Clinical Article  Evidence Based Medicine  Review Article
4Tracking early decline in cognitive function in older individuals at risk for Alzheimer disease dementia: the Alzheimer's disease cooperative study cognitive function instrumentJAMA Neurology  Clinical Article  Evidence Based Medicine
5Comparison of levetiracetam and sodium valproate in migraine prophylaxis: A randomized placebo-controlled studyAnnals of the Indian Academy of Neurology  Full Text  Clinical Article
6Seizures in patients with cerebral hemiatrophy: A prognostic evaluationAnnals of the Indian Academy of Neurology  Full Text  Clinical Article
7Cost-effectiveness estimate of prehospital thrombolysis: Results of the PHANTOM-S StudyNeurology┬«  Clinical Article
8Unilateral and bilateral upper limb dysfunction at body functions, activity and participation levels in people with multiple sclerosisMultiple Sclerosis Journal  Clinical Article
9Regulation of Treg-associated CD39 in multiple sclerosis and effects of corticotherapy during relapseMultiple Sclerosis Journal  Clinical Article
10Independent and combined effects of cognitive and physical activity on incident MCIAlzheimer's & Dementia  Clinical Article
1Reviving drugs with anti-stroke potential, minus side effectsEmory's Woodruff Health Sciences Center News
2Scientists uncover new role for neurotransmitter that helps fight infectionImperial College London Health News
3Perception of food consumption overrides realityHarvard Gazette - Health News
4A study will accurately identify genes involved in rare diseases affecting motoneuronIDIBELL-Bellvitge Biomedical Research Institute News
5Can coffee reduce your risk of MS?American Academy of Neurology News
6New study shows decreased aggressive behavior toward strangers in autism spectrum disorder modelScripps Research Institute News
7New TSRI study shows safer methods for stem cell culturingScripps Research Institute News
8MGH study identifies neurons that help predict what another individual will doMassachusetts General Hospital
9Revolutionary new probe zooms in on cancer cellsMontreal Neurological Institute and Hospital News
10New compounds protect nervous system from the structural damage characteristic of multiple sclerosisThe Mount Sinai Hospital

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L-carnitine levels have clinical significance in non-APOE4 carriers with mild AD

As reported in the Journal of Alzheimer’s Disease, the CSF L-carnitine levels are decreased in patients with early Alzheimer’s disease (AD) who are non-APOE4 carriers. Further, the L-carnitine levels are correlated with Aβ42 and the MMSE score. It is suggested that L-carnitine supplementation may be beneficial in non-APOE4 carriers with mild AD.

Moderate exercise has a positive effect on DPN

As reported in Diabetes and Its Complications, moderate exercise (40%-60% heart rate reserve) for 8 weeks resulted in significant improvement in nerve conduction velocity (peroneal and sural nerves) in patients with T2DM and clinical neuropathy (n=87) as compared with standard care.

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Clinical Pearls

Clinical Pearl from Smartest DocOlder adults who experience acute depression and have cognitive deficits in memory and executive function domains are at increased risk for developing dementia.

Clinical Pearl from Smartest DocLightning is a trigger for migraine headache.

Clinical Pearl from Smartest DocAmong both children and adults, CKD has a significant effect on brain structure, function, and associated behaviors.

The Top Read Articles of 2014 are Now Available

Scouring thousands of peer-reviewed journals and popular press, Our Editors just released the Top Read Articles of the Year. See the Top Read List