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See Latest ArticlesAutosomal Dominant Polycystic Kidney Disease: Current and Emerging Treatments
Kidney, 10/30/09
Villareal R et al. – Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common hereditary disorders. Attributing important roles to tubular cell ciliary functioning, cell proliferation and fluid secretion, subsequent alterations in levels of intracellular calcium, adenosine 3?,5?–cyclic monophosphate (cAMP) and activation of a variety of cellular kinases, including mammalian target of rapamycin (mTOR), has laid out the foundations for development of potentially effective treatments.
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