Nephrology

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Incidence and predictors of osteonecrosis among cyclosporin- or tacrolimus-treated renal allograft recipients
Rheumatology International, 11/04/09

Takao M et al. – There was a lower incidence of osteonecrosis of the hip and knee in renal allograft recipients treated with cyclosporin or tacrolimus. In the patients treated with improved immunosuppressive regimens, delayed graft function was a significant early predictor of osteonecrosis.

• The subjects were 232 renal allograft recipients who had MRI for osteonecrosis of the hip and knee 3 months or longer after transplant

• Evidence of osteonecrosis was visible on the MRI of 11 recipients (4.7%, 95% confidence interval 2.4–8.3)
• Univariate and multivariate logistic regression analyses indicated that delayed graft function was the most important predictor of osteonecrosis

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