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Atherton JC – Generation of HCO3? along the nephron is influenced by availability and pK of urinary buffers (e.g. acid phosphate, creatinine), renal tubular fluid pH and formation of ammonium salts (e.g. ammonium sulphate). Clinical conditions in which metabolic and respiratory changes in acid–base status occur are considered as are the compensatory mechanisms which limit changes in pH. Full correction of these disturbances requires removal of the primary disturbance.

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