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Non-Canonical TGF-Pathways, mTORC1 and Abl, in Renal Interstitial Fibrogenesis
American Journal of Physiology: Renal Physiology, 10/27/09
Wang S et al. – The findings indicate that non–canonical TGF[beta] pathways are activated during the early and rapid renal fibrogenesis of obstructive nephropathy. Moreover, the current findings suggest that combined inhibition of key regulators of these non–smad TGF pathways even in dose–sparing protocols are effective treatments in renal fibrogenesis.
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Ultrastructural changes in the glomerular filtration barrier and occurrence of proteinuria in Chinese patients with type 2 diabetic nephropathy
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