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Gotloib L – Use of the new multi–chambered low–GDP formulations brings about a remarkable biologic improvement in terms of damage to the monolayer. However, even though the magnitude of oxidative injury from glucose itself or its degradation products (or both) has been substantially reduced, it has not yet been eliminated. Consequently, and looking to the future, additional research aimed at the inclusion of biologic antioxidants in the improved new formulations would be welcomed.

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