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Different Doses of Oral Folic Acid for Homocysteine-Lowering Therapy in Patients on Hemodialysis: A Randomized Controlled Trial
Iranian Journal of Kidney Diseases, 10/13/09
Ossareh S et al. – Routine folic acid supplementation of 10 mg/d could not normalize plasma homocysteine levels in most of our patients. Increasing folic acid dose made a statistically significant but clinically trivial decrease in homocysteine levels, and could not normalize homocysteine level in most patients. Patients with a higher baseline homocysteine level achieved a greater reduction, which may be explained by primary noncompliance of some patient. Further investigation of folic acid dosage is suggested.
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