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Willicombe MK et al. – Catheters with multiple side holes are susceptible to seepage of the catheter locking solution through the side holes and therefore may be at greater risk of catheter thrombus formation. This may be exacerbated by the use of a hypertonic citrate lock given to just fill the internal catheter lumen because hyperosmolar locks are more likely to leave the catheter tip, resulting in increased risk of catheter associated thrombus.

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