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See Latest ArticlesMale gender results in more severe lupus nephritis
Rheumatology International, 10/05/09
de Carvalho JF et al. – These data suggest that male patients had a more severe LN compared to women diagnosed with this renal abnormality.
Methods- 81 patients diagnosed with SLE (ACR criteria) and active nephritis, who underwent renal biopsy between 1999 and 2004, and who had frozen serum samples and clinical data available from time of biopsy, selected for study
- Presence of anti-P and antichromatin antibodies measured using ELISA
- Anti-dsDNA measured using indirect immunofluorescence
- All of renal biopsies reviewed in blinded manner by same expert renal pathologist
- Charts extensively reviewed for demographic and renal features obtained at the time of the biopsy
- Of 81 patients (13.6%), 11 were male SLE patients
- Both male and female lupus patients of similar age and race, and had similar durations of lupus and renal disease
- Female patients had more cutaneous and haematological involvements than male SLE patients
- Articular data, CNS analyses, serositis findings and SLEDAI scores were similar in both experimental groups
- Positivity for anti-dsDNA, anti-ribosomal P and antichromatin did not differ between 2 groups, and both groups showed similarly low C3 or C4 serum levels
- Our analysis indicated no histopathological class of LN predominant in both males and females
- Serum creatinine levels higher in male SLE patients compared to the female SLE group, with an increased frequency of high creatinine as well as renal activity index
- Mean levels of proteinuria, cylindruria and serum albumin markedly altered , they were comparable between both lupus men and women
Jozélio F Carvalho, 10/05/09
| Male gender determines a worse prognosis in lupus patients with renal involvement, characterized by higher ceratinine and renal activity index on histopathological analysis. On the contarry, women had more skin and cytopania involvements than male SLE patients. |
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