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Low-dose indomethacin after ischemic acute kidney injury prevents down regulation of Oat1/3 and improves renal outcome
American Journal of Physiology: Renal Physiology, 10/01/09
Schneider R et al. – The study indicates that low dose indomethacin applied after ischemia prevents ischemia induced down regulation of Oat1/3 during reperfusion and has a substantial protective effect on kidney function after iAKI. The beneficial effect of low dose indomethacin on renal outcome is likely due to an effect different from inhibition of inflammation. In accordance to the decreased PAH net secretion, renal excretion of an endogenous organic anion (PGE2) is also impaired after ischemia and reperfusion.
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