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PTH transiently increases the percent mobile fraction of Npt2a in OK cells as determined by FRAP
American Journal of Physiology: Renal Physiology, 10/02/09
Weinman EJ et al. – The findings indicate that the association of Npt2a with PDZ binding proteins limits the lateral mobility of the transporter in the apical membrane of renal proximal tubule cells. Treatment with PTH, presumably by dissociating NHERF–1/Npt2a complexes, transiently increases the mobility of Npt2a suggesting that freeing of Npt2a from the cytoskeleton precedes PTH–mediated endocytosis.
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