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Positive Feedback Loop between Plasminogen Activator Inhibitor-1 and Transforming Growth Factor-Beta1 during Renal Fibrosis in Diabetes
American Journal of Nephrology, 09/25/09
Seo JY et al. – Since TGF–beta1 is well known to stimulate the PAI–1 promoter, we suggest that TGF–beta1 and PAI–1 together constitute a positive feedback loop in the development of renal fibrosis in diabetes.
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