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Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure
Human Molecular Genetics, 09/24/09

Ohta A et al. – Protein levels of ROMK and Maxi K were not changed, but epithelial Na channel appeared to be activated as a compensatory mechanism for the reduced NCC function. Thus, wild–type WNK4 is a positive regulator for the WNK–OSR1/SPAK–NCC cascade, and WNK4 is a potential target of anti–hypertensive drugs.

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Beyond office sphygmomanometry: Ways to better assess blood pressure
Cleveland Clinic Journal of Medicine, 11/05/09 Relevance Score: 71%

Aliskiren Monotherapy Does Not Cause Paradoxical Blood Pressure Rises. Meta-Analysis of Data From 8 Clinical Trials
Hypertension, 11/17/09 Relevance Score: 69%

Noninvasive cardiac output and blood pressure monitoring cannot replace an invasive monitoring system in critically ill patients
BMC Anesthesiology, 10/15/09 Relevance Score: 69%

Hypertension Highlights: Updates for European Guidelines, Plus New Evidence for Blood Pressure Targets and Strategies
Internet Source, 10/14/09 Relevance Score: 69%

Blood pressure lowering efficacy of coenzyme Q10 for primary hypertension
Cochrane Reviews, 10/09/09 Relevance Score: 69%