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Outcome of Subclinical Antibody-Mediated Rejection in Kidney Transplant Recipients with Preformed Donor-Specific Antibodies
American Journal of Transplantation, 09/25/09

Loupy A et al. – SAMR is a frequent entity in KTR with preexisting DSAs and promotes subsequent GFR impairment and development of chronic AMR. C4d–negative SAMR patients displayed an intermediate course between the no–SAMR group and the C4d+ SAMR group. Screening biopsies may be useful to recognize patients more likely to develop SAMR.

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Alexandre Loupy, 10/04/09

In this paper, we assess the histological lesions at 3 months and 1 year in patients receiving deceased-donor grafts, comparing those with preformed DSA to those without. We evaluated the prevalence of the new entity subclinical antibody-mediated rejection in DSA-positive patients, and correlated the lesions found with immunologic parameters and functional parameters to further determine the impact of SAMR on subsequent graft outcome.

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