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Protein-bound uraemic toxin removal in haemodialysis and post-dilution haemodiafiltration
Nephrology Dialysis Transplantation, 09/22/09

Krieter DH et al. – The elimination of protein–bound compounds into dialysate is predicted by the level of pre–treatment plasma concentrations and depends particularly on diffusion. Lacking enhanced removal in online post–dilution haemodiafiltration emphasizes the minor significance of convection for the clearance of these solutes. Compared to LMW proteins, the highly protein–bound toxins pCS and IS are less effectively eliminated with all treatment forms. For a sustained decrease of pCS and IS plasma levels, alternative strategies promise to be more efficient therapy forms.

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