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Mesangial cell-derived factors alter monocyte activation and function through inflammatory pathway: possible pathogenic role in diabetic nephropathy
American Journal of Physiology: Renal Physiology, 09/10/09
Min D et al. – The authors results show that mesangial cell secreted factors increase monocyte adhesion, differentiation, MMP expression and degradative capacity. High glucose could augment these effects by increasing mesangial cell proinflammatory cytokine secretion. This mesangial cell/monocyte interaction may be important in activating monocytes to migrate from the circulation to the kidney in the early stages of diabetic nephropathy.
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