Nephrology Medical News about WD

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P53 Regulates Metanephric Development
Journal of the American Society of Nephrology, 09/09/09

Saifudeen Z et al. – Unlike several other models of UB ectopia, hypersensitivity of p53–/– WD to GDNF is not accompanied by reduced Sprouty–1 or anterior expansion of the GDNF domain. The data lend support for a restrictive role for p53 activity in UB outgrowth from the WD.

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