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See Latest ArticlesInterplay between Akt and p38 MAPK Pathways in the Regulation of Renal Tubular Cell Apoptosis Associated with Diabetic Nephropathy
American Journal of Physiology: Renal Physiology, 09/03/09
Rane MJ et al. – The results collectively suggest that down–regulation of Akt activation during long term hyperglycemia contributes to enhanced p38 MAPK activation and RPTC apoptosis. Mechanism of down–regulation of Akt activation in 6 months STZ diabetic kidneys was attributed to decreased Akt–Hsp25, Akt–p38 interaction and decreased PTEN activity. Thus, PTEN or Hsp25 could serve as potential therapeutic targets to modulate Akt activation and control p38 MAPK–mediated diabetic complications.
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