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The instructive role of metanephric mesenchyme on ureteric bud patterning, sculpting and maturation
American Journal of Physiology: Renal Physiology, 09/03/09

Shah MM et al. – The morphological changes induced by MM were accompanied by a reassignment of GFR1 (a receptor for GDNF) to tips. Such "quality control" by the MM upon UB morphology may provide resiliency to the branching program. This may help to explain a number of knockout phenotypes in which branching and/or cystic defects are less impressive than expected. A second hit in the MM may thus be necessary to make these defects fully apparent.

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