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See Latest ArticlesPresence of intratumoral neutrophils is an independent prognostic factor in localized renal cell carcinoma
Journal of Clinical Oncology, 09/04/09
Jensen HK et al. – The presence of intratumoral neutrophils is a new, strong, independent prognostic factor for short recurrence-free, cancer-specific, and overall survival in localized clear cell RCC
Methods- 121 consecutive patients who had a nephrectomy for localized RCC
- Biomarkers (intratumoral CD8+, CD57+ immune cells, CD66b+ neutrophils, and carbonic anhydrase IX [CA IX]) were assessed by immunohistochemistry, and the relationship with clinical and histopathologic features and patient outcome was evaluated
- The intratumoral neutrophils ranged from zero to 289 cells/mm2 tumor tissue
- The presence of intratumoral neutrophils was statistically significantly associated with increasing tumor size, low hemoglobin, high creatinine, and CA IX 85%
- In multivariate analysis, the presence of intratumoral neutrophils pT stage T3b/T4, and low hemoglobin were independent prognostic factors significantly associated with short RFS
- The presence of intratumoral neutrophils was also an independent prognostic factor for cancer-specific survival and OS
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