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Therapeutic Potential of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Inhibitors in Polycystic Kidney Disease
BioDrugs, 08/28/09
Li H et al. – Cyst growth in ADPKD involves fluid accumulation within the cyst lumen driven by cystic fibrosis transmembrane conductance regulator (CFTR)–mediated transepithelial Cl– secretion. This suggests that inhibitors of the CFTR Cl– channel might retard cyst growth.
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