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Repulsion between Lys258 and upstream arginines explains the missorting of the AQP2 mutant p.Glu258Lys in nephrogenic diabetes insipidus
Human Mutation, 08/25/09
Kamsteeg EJ et al. – The data reveal that the RRRxxxKL motif and repulsion between K258 and the arginine–triplet within this motif are the primary cause of missorting of AQP2–E258K in NDI.
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