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ESRD Impairs Nonrenal Clearance of Fexofenadine but not Midazolam
Journal of the American Society of Nephrology, 08/24/09
Nolin TD et al. – Changes in hepatocyte and enterocyte protein expression in the presence of uremic serum were consistent with in vivo results. These findings demonstrate a mechanism for altered drug disposition in kidney disease, which may partially account for the high rates of drug toxicity in this population.
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