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QRS duration predicts sudden cardiac death in hypertensive patients undergoing intensive medical therapy: The LIFE study
European Heart Journal, 08/21/09
Morin DP et al. – In the setting of aggressive antihypertensive therapy, prolonged QRS duration identifies hypertensive pts at higher risk for sudden cardiac death (SCD), even after controlling for left bundle branch block, other known risk factors for SCD, and changes in blood pressure and severity of left ventricular hypertrophy.
Methods- Study of whether QRS duration predicts SCD in pts with left ventricular hypertrophy and treated hypertension
- Over 4.8 ± 0.9 yrs follow-up of 9193 hypertensive pts with electrocardiographic evidence of LVH treated with atenolol- or losartan-based regimens, SCD for 178 pts (1.9%)
- In multivariable analysis including randomized treatment, changing blood pressure over time, and baseline differences between pts with/without SCD, QRS duration was independently predictive of SCD
- Baseline QRS duration remained a significant predictor of SCD even after controlling for presence/absence of left bundle branch block and for changes in ECG LVH severity over study course
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