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Effects of Arterial Port Design on Blood Flow Distribution in Hemodialyzers
Blood Purification, 08/18/09

Kim JC et al. – The arterial port design of hemodialyzers should be optimized such that jet flow and vortices do not impair dialysis efficiency and biocompatibility.

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Jeong Chul Kim and Ji Hyun Kim, 08/18/09

Based on this artificle, we can think about the optimmal geometry of hemodialyzer arterial port. As you know arterial port is the most ciritical point in terms of prssure gradient - abrupt change in diameter of blood flow path from several mm (arterial port) to 200 um (hollow fiber) exposes high pressure gradient to blood cells aroud the bottleneck region. In relation to this, SEM (Scanning Electron Microscope) study results (not published yet) showed blood clot that blocking the lumen of hollow fibers in arterial port of hemodialyzer. We are now trying to integrate the blood and dialysate flow profiles and therr effects of membrane fouling development patterns according to the operating codition of renal replacement therpy (HDF vs. HD).

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