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See Latest ArticlesRapamycin has dual opposing effects on proteinuric experimental nephropathies: is it a matter of podocyte damage
Nephrology Dialysis Transplantation, 08/17/09
Torras J et al. – Rapamycin has dual opposing effects on subjacent renal lesion, with proteinuria and podocyte damage aggravation in the glomerular model and a nephro–protective effect in the chronic inflammatory tubulointerstitial model. Rapamycin produces slight alterations in podocyte structure when acting on healthy podocytes, but it clearly worsens those podocytes damaged by other concomitant injury.
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