Nephrology Medical News about Medullary Collecting Ducts

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Epac Regulates UT-A1 to Increase Urea Transport in Inner Medullary Collecting Ducts
Journal of the American Society of Nephrology, 08/07/09

Sands JM et al. – Activation of Epac increases urea transport, accumulation of UT–A1 at the plasma membrane, and UT–A1 phosphorylation, the latter of which is mediated by the MEK–ERK pathway.

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Jeff M. Sands, 08/07/09

Urea and urea transporters play key roles in the urinary concentrating mechanism within the renal inner medulla. Vasopressin is the primary hormone regulating the urine concentrating mechanism. Vasopressin is traditionally thought to act via cAMP to stimulate PKA. The major finding in this study is the identification of a second pathway by which vasopressin and cAMP stimulate urea transport: the Epac pathway. Epac activation results in a functional change in urea transport in perfused rat terminal IMCDs. The increase in urea transport results, at least in part, from Epac-stimulated increases in UT-A1 phosphorylation and plasma membrane accumulation. To our knowledge, this is the first demonstration that the Epac pathway regulates urea transport in the kidney.

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