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Phase II Study of Axitinib in Sorafenib-Refractory Metastatic Renal Cell Carcinoma
Journal of Clinical Oncology, 08/07/09
Rini BI et al. – Axitinib has antitumor activity in patients with mRCC refractory to prior VEGF–targeted therapy, including sorafenib. Toxicities were mild to moderate and were manageable. A randomized, phase III trial to compare axitinib with sorafenib in patients who have mRCC refractory to one prior first–line therapy regimen is underway.
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