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See Latest ArticlesThe Ste20-like Kinase, SLK, Promotes p53 Transactivation and Apoptosis
American Journal of Physiology: Renal Physiology, 08/05/09
Cybulsky AV et al. – Overexpression of SLK amplified apoptosis induced by subjecting cells to in vitro ischemia–reperfusion injury, while ectopic expression of a dominant negative SLK mutant attenuated the ischemia–reperfusion–induced apoptosis. The p53 transactivation inhibitor, pifithrin–alpha, significantly attenuated the amount of apoptosis after ischemia–reperfusion and SLK overexpression. Thus, SLK induces p53 phosphorylation and transactivation, which enhances apoptosis after in vitro ischemia–reperfusion injury.
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