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Simvastatin Reverses Podocyte Injury but not Mesangial Expansion in Early Stage Type 2 Diabetes Mellitus
Renal Failure, 07/29/09
Wei P et al. – The immuno–staining of nephrin, a protein marker of the integrity of podocyte slit diaphragms, was decreased in HF–vehicle; however, the nephrin quantity of the HF–SMV group was not different from ND–vehicle. It is concluded that SMV reverses podocyte damage, but does not affect mesangial expansion in the kidneys of early stage proteinuria of type 2 DM.
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