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Post-renal transplantation hypophosphatemia
Pediatric Nephrology, 07/31/09

Sakhaee K – An understanding of the pathophysiologic mechanisms of post–renal transplant (PRT) bone disease is of important clinical significance. Although bone disease occurs after all solid organ transplantation, the cumulative skeletal fracture rate remains high in PRT subjects while reaching a plateau with other transplantations. It is unclear as of yet whether these factors alone or in conjunction with excess parathyroid hormone (PTH) secretion play a key role in the development of negative Pi balance and consequent bone disease in this population.

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