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Investigation of hypoxia and carbonic anhydrase IX expression in a renal cell carcinoma xenograft model with oxygen tension measurements and 124I-cG250 PET/CT
Urologic Oncology: Seminars and Original Investigations, 07/30/09
Lawrentschuk N et al. – Intratumoral hypoxia does exist within a human RCC xenograft model using invasive oxygen probe measurements. 124I–cG250 targets RCC with correlation between uptake on noninvasive PET–CT studies and traditional biodistribution studies opening the possibility of using PET/CT in future studies. Finally, CAIX expression was not related to hypoxia in this model, supporting the hypothesis that cell lines may subvert known hypoxia mechanisms in hypoxic environments.
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