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Estimating GFR using serum beta trace protein: accuracy and validation in kidney transplant and pediatric populations
Kidney International, 07/23/09
White CA et al. – The limitations of estimates of glomerular filtration rate (GFR) based only on serum creatinine measurements have spurred an interest in more sensitive markers of GFR. Beta–trace protein (BTP), a low–molecular–weight glycoprotein freely filtered through the glomerular basement membrane and with minimal non–renal elimination, may be such a marker. The results were an improvement compared to the MDRD and Schwartz equations, both of which had high median bias and reduced accuracy. The updated Schwartz equation also performed well.
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