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(Click the title below to leave the MDLinx Network and go to the Journal's Website)

Isakova T et al. - The diagnosis of chronic kidney disease (CKD) confers dismal clinical outcomes regardless of whether patients are initiating dialysis and face a median survival of only 2–3 years or they have earlier-stage CKD and face a risk of death that is greater than the risk of progression to dialysis. This commentary considers the justification and challenges for such trials and presents a 'first-draft' blueprint of distinct trial approaches to initiate a dialog that will ultimately culminate in studies aimed at improving survival across the spectrum of CKD.

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