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EGFR-PLCgamma1 Signaling Mediates High Glucose-Induced PKC1-Akt Activation and Collagen I Upregulation in Mesangial Cells
American Journal of Physiology: Renal Physiology, 07/16/09
Wu D et al. - The results indicate that EGFR-PLCgamma1 signaling mediates HG-induced PKCbeta1-Akt activation and subsequent collagen I upregulation in MC. Inhibition of EGFR or PLCgamma1 may provide attractive therapeutic targets for the treatment of diabetic nephropathy.
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