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See Latest ArticlesRisk of bilateral renal cell cancer
Journal of Clinical Oncology, 07/29/09
Wiklund F et al. - In a trial to ascertain the risk of developing bilateral kidney cancer, it was concluded that the risk of metachronous bilateral renal cell cancer (RCC) is drastically higher among pts first affected at a young age, suggesting a subset of early onset RCC with a strong genetic component.
Methods- The risk of metachronous bilateral RCC was estimated in pts diagnosed with unilateral kidney cancer, as recorded in the nationwide cancer registries of Norway and Sweden.
- 28,642 pts were followed for an average of 4.4 yrs.
- The standardized incidence ratio was used as a measure of relative risk.
- Multivariate Poisson regression was used to separate the effects of the explanatory variables.
- A synchronous bilateral RCC was reported in 86 pts.
- 112 metachronous bilateral cancers were recorded during 126,493 person-yrs of follow-up compared with 35.8 expected, yielding an overall relative risk (RR) of 3.1 and a cumulative incidence of 0.8% after 20 or more years of follow-up.
- In multivariate analyses, risk increased monotonically with younger age at first diagnosis; compared with pts who were 60 yrs or older, those younger than 40 yrs were at a 17-fold higher risk.
- A modest but statistically significant decreasing trend with increasing duration of follow-up was found.
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