Nephrology Medical News about Silymarin; ferric nitrilotriacetate; NF?B; oxidative stress; tumor promotion

Become a Member Today!
Register

Most Viewed Abstracts

1. Report Shows Shift in Starting Salaries for Physicians

2. 2008 Exclusive Survey—Earnings: Good news for primary care income

3. Medicare pay-for-reporting effort draws fire from frustrated doctors

4. Allopurinol-induced recurrent dress syndrome: Pathophysiology and treatment

5. Debunking Myths in the US Healthcare System

Your Article Summary

See Latest Articles

(Click the title below to leave the MDLinx Network and go to the Journal's Website)

Dietary supplementation of silymarin protects against chemically induced nephrotoxicity, inflammation, and renal tumor promotion response
Investigational New Drugs, 07/15/09

Kaur G et al. - In a trial to explore protective effect of silymarin against Fe-NTA-mediated renal oxidative stress, inflammation, and tumor promotion response along with elucidation of the implicated mechanism(s), it was found that silymarin markedly protects against chemically-induced renal cancer and acts plausibly by virtue of its antioxidant, anti-inflammatory, and antiproliferative activities.

Methods

Administration of Fe-NTA (10 mg/kg bd wt, i.p.) to Swiss albino mice induced marked oxidative stress in kidney, evident from augmentation in renal metallothionein (MT) expression, depletion of glutathione content and activities of antioxidant and phase II metabolizing enzymes, and enhancement in production of aldehyde products such as 4-hydroxy-2-nonenal.

Results

Fe-NTA significantly activated nuclear factor kappa B (NFκB) and upregulated expression of downstream genes: cyclooxygenase 2 and inducible nitric oxide synthase and enhancing the production of proinflammatory cytokines: tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6).
Feeding of 0.5% and 1% silymarin diet conferred a significant protection against Fe-NTA-induced oxidative stress and inflammation.
It further augmented MT expression, restored the antioxidant armory, ameliorated NFκB activation, and decreased the expression of proinflammatory mediators.
Silymarin also suppressed Fe-NTA-induced hyperproliferation in kidney, ameliorating renal ornithine decarboxylase activity, and DNA synthesis.

<< Previous
Sunitinib and bevacizumab for first-line treatment of metastatic...

Next >>
Downregulation of Claudin-2 Expression in Renal Epithelial Cells...