Nephrology Medical News about Behcet?s disease, Glomerulonephritis, Hematuria

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Renal involvement in Behcet's disease
Saudi Journal of Kidney Diseases and Transplantation, 07/21/09

Ardalan MR et al. – Study concludes that renal involvement in Behcet's disease (BD) is not infrequent, although in most cases it is mild in nature and may be missed.

Methods

An investigation of the frequency and type of renal involvement in BD pts in Azerbaijan province, one of the prevalent areas of BD in Iran
All cases of BD were evaluated for renal dysfunction in a f/u between June 2004-Jan 2007, and evaluated for:
- Serum creatinine > 1.7 mg/dL
- Glomerular hematuria and proteinuria
Those pts with proteinuria >500 mg/d and serum creatinine level >2 mg/dL, underwent renal biopsy

Results

100 pts, 6% had obvious renal involvements
4 pts had glomerular hematuria and proteinuria
Renal biopsy in 2 of them revealed measangial proliferative glumerulonephritis with IgA deposit in 1 of them and membranoproliferative glumerolonephritis in another one
2 remaining pts had serum creatinine >2 mg/dL w/o any hematuria or proteinuria
Serologic study for viral agents and collagen vascular disease were negative in all pts with renal involvements

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