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Downregulation of Claudin-2 Expression in Renal Epithelial Cells by Metabolic Acidosis
American Journal of Physiology: Renal Physiology, 07/15/09

Balkovetz DF et al. - Chronic metabolic acidosis (CMA) is associated with an inhibition of fluid reabsorption in the renal proximal tubule. CMA downregulates the expression of claudin-2 likely through a direct effect of acidic pH. Potential physiological significance of these changes is discussed.

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Today in Acid-Base...keeping you current

Activation of p53 Promotes Renal Injury in Acute Aristolochic Acid Nephropathy
Journal of the American Society of Nephrology, 11/23/09

Torsades de Pointes induced by a combination of garenoxacin and disopyramide and other cytochrome P450, family 3, subfamily A polypeptide-4-influencing drugs during hypokalemia due to licorice
Clinical and Experimental Nephrology, 11/18/09

Autosomal dominant pseudohypoaldosteronism type 1 with a novel splice site mutation in MR gene
BMC Nephrology, 11/16/09

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Today in Basic Science/Genetics...keeping you current

Association of the PPARGC1A Gene Polymorphism With Diabetic Nephropathy in an Asian Indian Population (CURES-41)
Metabolic Syndrome and Related Disorders, 11/25/09

Endothelial Progenitor Cells Possess Monocyte-like Antigen-presenting and T-cell-Co-stimulatory Capacity
Transplantation, 11/25/09

The Biology of the (Pro)Renin Receptor
Journal of the American Society of Nephrology, 11/25/09

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