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See Latest ArticlesCharacterization of the kinase activity of a WNK4 protein complex
American Journal of Physiology: Renal Physiology, 07/09/09
Ahlstrom R et al. - Mutations in WNK4 protein kinase cause pseudohypoaldosteronism type II (PHAII), a genetic disorder that is characterized by renal NaCl and K+ retention leading to hypertension and hyperkalemia. Consistent with this, WNK4 is known to regulate several renal tubule transporters, including the NaCl cotransporter, NCC, and the K+ channel, ROMK, but the mechanisms are incompletely understood, and the role of the kinase activity in its actions is highly controversial.
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